Ionis Pharmaceuticals, Inc. is the 49th largest of 352 graded companies. Showing 5 of them, including IONS itself. 245 more are in this industry but have no grade yet, so they are left out rather than shown blank.
| Company | Grade | Market value | Revenue | Profit margin | Free cash flow | Price to earnings |
|---|---|---|---|---|---|---|
| Crinetics Pharmaceuticals, Inc.CRNX | D- | — | $42.2M | -1,189.9% | -$425.2M | — |
| OSR Health, Inc.OSRH | D- | — | $1.7M | -781.5% | — | — |
| Lunai Bioworks Inc.LNAI | B | — | $52K | -6,852.0% | -$5.3M | — |
| Barinthus Biotherapeutics plcBRNS | D- | — | $0.00 | — | -$26.4M | — |
| Ionis Pharmaceuticals, Inc.IONS | F- | $4.8B | $960.1M | -56.9% | -$616.3M | — |
347 more biotechnology companies
Graded on the same five checks, from their own SEC filings.
Three ratings, each a percentile against the 582 companies we cover in Biotechnology. Deliberately kept apart rather than blended into one score — cheap, rising and well-run are three different facts, and a single number would hide which one is which.
Middle of its industry
The most recent month is left out on purpose: returns tend to persist over 7–12 months and the newest one tends to reverse. This describes what the price has done, and says nothing about what it will do.
Middle of its industry
Yields, so higher means cheaper — a loss-making company ranks last instead of dropping out. Cheap is not the same as good: a high yield is often a price that fell for a reason. Blended from 4 of 5 measures.
2 checks not reported
What management does with the money — scored on whatever the filings answer, never as a share of the total.
A description of where this company sits among its competitors, not a recommendation. Ratings updated Nov 14, 2026.
A blank price-to-earnings means a loss, not a missing figure — the ratio has no meaning when there are no earnings to divide by, and printing a negative one would make the least profitable company look the cheapest.
Grades are trailing twelve months from each company’s own SEC filings, so they move only when a company files. Every column is computed by the same code that graded Ionis Pharmaceuticals, Inc. on the overview — nothing here comes from a data vendor’s own ratios.
Industry membership is not a judgement about how similar two businesses are. It groups companies by what they are classified as, which is a starting point for comparison rather than a claim that they compete.
$29.06+6.4%Nov 13 close
Figures through September 30, 2026, from the 10-Q filed November 9, 2026
Company outlook: revenue of $875M to $900M for Fiscal year 2026 — down 6.0% on a year earlier ($943.7M)