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Every company here put through the same five checks on growth and cash generation. It describes the industry as it reports today — not which of these to buy.
| VRTX | VERTEX PHARMACEUTICALS INC / MA | B+ | $138.7B | $547.02 | 35.22 | $13B | 30.7% |
| REGN | REGENERON PHARMACEUTICALS, INC. | C+ | $101.3B | $959.45 | 21.18 | $16.9B | 28.5% |
| MRNA | Moderna, Inc. | C- | $100.6B | $248.70 | — | $2.5B | -110.5% |
| ARGX | ARGENX SE | not rated | $60.5B | $977.29 | 49.94 | — | — |
| ONC | BEONE MEDICINES LTD. | A+ | $48B | $420.06 | 53.85 | $6.6B | 13.9% |
| RPRX | Royalty Pharma plc | C+ | $40.1B | $69.97 | 45.73 | $2.6B | 25.7% |
| RVMD | Revolution Medicines, Inc. | F | $39.1B | $180.66 | — | $0.00 | — |
| ROIV | ROIVANT SCIENCES LTD. | B- | $30.3B | $41.85 | — | $41.1M | -838.2% |
| INSM | INSMED INC | C- | $26.5B | $120.64 | — | $1.5B | -39.9% |
| INCY | INCYTE CORPORATION | C | $24.9B | $122.23 | 65.01 | $6B | 6.7% |
| BNTX | BioNTech SE | F | $22B | $87.64 | — | $2.7B | -60.9% |
| ALNY | ALNYLAM PHARMACEUTICALS, INC. | B+ | $21.4B | $159.80 | 68.58 | $3.7B | 71.3% |
| NCNA | NUCANA PLC | not rated | $19.5B | $0.94 | — | — | — |
| EXEL | EXELIXIS, INC. | A+ | $17.3B | $70.71 | 21.17 | $2.5B | 35.5% |
| ASND | Ascendis Pharma A/S | D | $16.1B | $259.10 | — | $1.2B | -21.8% |
| JAZZ | Jazz Pharmaceuticals plc | A | $15.9B | $248.18 | 80.84 | $4.7B | 4.4% |
| BBIO | BridgeBio Pharma, Inc. | B | $15.5B | $79.53 | — | $945.5M | -60.7% |
| SMMT | Summit Therapeutics Inc. | not rated | $13.3B | $16.63 | — | — | — |
| AKTX | Akari Therapeutics Plc | not rated | $11.9B | $7.62 | — | — | — |
| HALO | HALOZYME THERAPEUTICS, INC. | A+ | $11.6B | $101.69 | 25.36 | $1.8B | 26.9% |
| KYMR | KYMERA THERAPEUTICS, INC. | F- | $11.5B | $134.90 | — | $102.2M | -341.8% |
| TECH | BIO-TECHNE Corp | A+ | $11.4B | $72.78 | 66.77 | $1.2B | 14.0% |
| BMRN | BioMarin Pharmaceutical Inc | B | $11.3B | $58.32 | — | $3.7B | -0.5% |
| PCVX | VAXCYTE, INC. | not rated | $10.9B | $68.62 | — | — | — |
| SYRE | SPYRE THERAPEUTICS, INC. | D | $10.1B | $106.77 | — | $0.00 | — |
| MDGL | MADRIGAL PHARMACEUTICALS, INC. | B- | $10.1B | $432.64 | — | $1.4B | -10.9% |
| TGTX | TG THERAPEUTICS, INC. | A+ | $9.9B | $65.75 | 98.13 | $897.8M | 11.8% |
| PRAX | PRAXIS PRECISION MEDICINES, INC. | F | $9.7B | $346.46 | — | $0.00 | — |
| KRYS | Krystal Biotech, Inc. | A+ | $9.2B | $308.82 | 41.90 | $470M | 47.9% |
| PTGX | PROTAGONIST THERAPEUTICS, INC. | A+ | $8.8B | $134.76 | 28.61 | $551.7M | 62.0% |
| CORT | CORCEPT THERAPEUTICS INC | A+ | $8.2B | $74.52 | 58.68 | $963.6M | 16.8% |
| CYTK | CYTOKINETICS, INCORPORATED | D | $8.2B | $58.52 | — | $113.3M | -686.6% |
| AXSM | AXSOME THERAPEUTICS, INC. | B- | $7.8B | $149.20 | — | $865.3M | -18.2% |
| RYTM | RHYTHM PHARMACEUTICALS, INC. | C- | $7.8B | $112.18 | — | $280.7M | -69.0% |
| TWST | Twist Bioscience Corporation | C- | $7.7B | $122.71 | — | $459.4M | -28.3% |
| IMVT | Immunovant, Inc. | not rated | $7.7B | $37.04 | — | — | — |
| ORKA | Oruka Therapeutics, Inc. | not rated | $7.3B | $107.10 | — | — | — |
| ABVX | Abivax S.A. | not rated | $7.2B | $91.37 | — | — | — |
| IBRX | IMMUNITYBIO, INC. | C | $7.1B | $6.67 | — | $182.6M | -607.8% |
| CAI | CARIS LIFE SCIENCES, INC. | A | $7B | $24.50 | 14.76 | $1B | 9.2% |
| ARWR | ARROWHEAD PHARMACEUTICALS, INC. | F- | $7B | $49.36 | — | $450.8M | -160.6% |
| KOD | Kodiak Sciences Inc. | not rated | $6.9B | $109.23 | — | — | — |
| MANE | Veradermics, Inc | not rated | $6.6B | $156.30 | — | — | — |
| CGON | CG Oncology, Inc. | F- | $6.5B | $72.66 | — | $6.2M | -3,851.1% |
| LGND | LIGAND PHARMACEUTICALS INCORPORATED | C | $6.3B | $317.16 | 137.90 | $253.8M | 20.3% |
| MIRM | Mirum Pharmaceuticals, Inc. | D- | $6.2B | $94.64 | — | $670.8M | -134.8% |
| BLTE | Belite Bio, Inc | not rated | $6.1B | $155.94 | — | — | — |
| ERAS | ERASCA, INC. | not rated | $5.9B | $16.80 | — | — | — |
| SRRK | SCHOLAR ROCK HOLDING CORPORATION | F- | $5.7B | $46.54 | — | $570K | -72,563.2% |
| PTCT | PTC Therapeutics, Inc. | D | $5.4B | $64.87 | — | $1.2B | -9.2% |
| EWTX | Edgewise Therapeutics, Inc. | not rated | $5.2B | $47.58 | 5.82 | — | — |
| COGT | Cogent Biosciences, Inc. | not rated | $5.1B | $29.39 | — | — | — |
| DNTH | Dianthus Therapeutics, Inc. | F- | $5B | $89.24 | — | $2M | -9,927.5% |
| TVTX | TRAVERE THERAPEUTICS, INC. | F- | $5B | $52.06 | — | $651M | -18.7% |
| DFTX | Definium Therapeutics, Inc. | not rated | $4.7B | $34.46 | — | — | — |
| IONS | IONIS PHARMACEUTICALS, INC. | F- | $4.7B | $28.31 | — | $960.1M | -56.9% |
| GPCR | Structure Therapeutics Inc. | not rated | $4.5B | $20.98 | — | — | — |
| CRSP | CRISPR THERAPEUTICS AG | F- | $4.5B | $45.89 | — | $25.2M | -1,812.1% |
| TNGX | TANGO THERAPEUTICS, INC. | F | $4.4B | $25.71 | — | $0.00 | — |
| RLAY | RELAY THERAPEUTICS, INC. | D- | $4.4B | $19.71 | — | $10.4M | -2,837.0% |
| ZLAB | ZAI LAB LIMITED | F- | $4.3B | $26.43 | — | $441.7M | -44.9% |
| XENE | Xenon Pharmaceuticals Inc. | F | $4.1B | $42.09 | — | $0.00 | — |
| IRON | Disc Medicine, Inc. | not rated | $4B | $87.11 | — | — | — |
| ABCL | AbCellera Biologics Inc. | C- | $3.9B | $11.94 | — | $67.9M | -218.5% |
| TARS | TARSUS PHARMACEUTICALS, INC. | B- | $3.8B | $76.71 | — | $682.2M | -102.9% |
| ELVN | ENLIVEN THERAPEUTICS, INC. | not rated | $3.8B | $51.17 | — | — | — |
| DBVT | DBV TECHNOLOGIES S.A. | F- | $3.7B | $11.91 | — | $3.8M | -5,405.3% |
| IOVA | IOVANCE BIOTHERAPEUTICS, INC. | B- | $3.7B | $8.08 | — | $379M | -58.2% |
| PBLS | Parabilis Medicines, Inc. | not rated | $3.7B | $29.64 | — | — | — |
| VKTX | VIKING THERAPEUTICS, INC. | F | $3.6B | $28.43 | — | $0.00 | — |
| LEGN | Legend Biotech Corp | C- | $3.6B | $19.54 | — | $1.1B | -22.0% |
| ARQT | ARCUTIS BIOTHERAPEUTICS, INC. | B | $3.6B | $28.36 | 135.05 | $508.7M | 5.9% |
| VRDN | Viridian Therapeutics, Inc./DE | F- | $3.5B | $31.24 | — | $26.3M | -1,724.1% |
| GMAB | Genmab A/S | B+ | $3.4B | $53.87 | 3.50 | $3.9B | 21.0% |
| DYN | Dyne Therapeutics, Inc. | not rated | $3.4B | $17.98 | — | — | — |
| TLX | Telix Pharmaceuticals Limited | D | $3.3B | $9.73 | — | $890.8M | 3.8% |
| ACAD | ACADIA PHARMACEUTICALS INC. | B+ | $3.2B | $18.35 | 8.66 | $1.2B | 30.1% |
| DNLI | Denali Therapeutics Inc. | F | $3.2B | $19.73 | — | $0.00 | — |
| IDYA | IDEAYA Biosciences, Inc. | F- | $3.2B | $32.69 | — | $36.5M | -1,149.6% |
| CELC | CELCUITY INC. | not rated | $3.2B | $64.31 | — | — | — |
| VCEL | VERICEL CORPORATION | A | $3B | $59.40 | 92.81 | $324.2M | 10.3% |
| XNCR | Xencor, Inc | D- | $3B | $39.99 | — | $200.5M | -58.8% |
| ADMA | ADMA BIOLOGICS, INC. | B+ | $2.9B | $13.19 | 17.13 | $519.2M | 35.1% |
| MBX | MBX Biosciences, Inc. | not rated | $2.9B | $57.49 | — | — | — |
| RCUS | Arcus Biosciences, Inc. | F- | $2.7B | $18.80 | — | $100M | -453.0% |
| BEAM | Beam Therapeutics Inc. | F- | $2.7B | $25.79 | — | $146.6M | -73.9% |
| NAMS | NewAmsterdam Pharma Company N.V. | D- | $2.5B | $20.75 | — | $25.9M | -789.9% |
| PVLA | Palvella Therapeutics, Inc. | not rated | $2.4B | $163.83 | — | — | — |
| CLDX | Celldex Therapeutics, Inc. | F- | $2.4B | $30.14 | — | $158K | -195,608.9% |
| SEPN | Septerna, Inc. | F- | $2.3B | $48.54 | — | $96.3M | -61.3% |
| BHVN | Biohaven Ltd. | not rated | $2.3B | $15.20 | — | — | — |
| IMNM | Immunome Inc. | F | $2.3B | $19.07 | — | $0.00 | — |
| VIR | Vir Biotechnology, Inc. | C- | $2.2B | $13.12 | — | $302.8M | -61.0% |
| RXRX | RECURSION PHARMACEUTICALS, INC. | D- | $2.2B | $3.59 | — | $68.2M | -697.1% |
| PHVS | Pharvaris N.V. | not rated | $2.2B | $34.12 | — | — | — |
| VERA | Vera Therapeutics, Inc. | not rated | $2.2B | $30.44 | — | — | — |
| LKFT | GALAPAGOS NV | D | $2.2B | $33.38 | 6.14 | $1.2B | 28.9% |
| AUPH | Aurinia Pharmaceuticals Inc. | A+ | $2.2B | $16.21 | 7.08 | $321.7M | 97.7% |
| TRAX | FIRST TRACKS BIOTHERAPEUTICS, INC. | not rated | $2.1B | $50.53 | — | — | — |
| TRVI | TREVI THERAPEUTICS, INC. | not rated | $2.1B | $14.82 | — | — | — |
| REPL | REPLIMUNE GROUP, INC. | not rated | $2.1B | $21.76 | — | — | — |
| HRMY | HARMONY BIOSCIENCES HOLDINGS, INC. | B+ | $2B | $34.23 | 11.30 | $989.4M | 18.1% |
| MAZE | MAZE THERAPEUTICS, INC. | not rated | $2B | $36.72 | — | — | — |
| ZYME | ZYMEWORKS INC. | F+ | $2B | $29.03 | 55.83 | $266M | 16.3% |
| MRVI | Maravai LifeSciences Holdings, Inc. | D- | $2B | $7.70 | — | $213M | -30.8% |
| FTRE | Fortrea Holdings Inc. | C | $2B | $20.38 | — | $2.7B | -2.6% |
| AGIO | AGIOS PHARMACEUTICALS, INC. | C- | $2B | $32.83 | — | $140.8M | -264.8% |
| ZBIO | Zenas BioPharma, Inc. | F- | $1.9B | $28.68 | — | $10M | -5,418.1% |
| BRVE | Braveheart Bio, Inc. | not rated | $1.9B | $20.83 | — | — | — |
| KLRA | Kailera Therapeutics, Inc. | not rated | $1.9B | $14.38 | — | — | — |
| COAG | Hemab Therapeutics Holdings, Inc. | not rated | $1.8B | $39.23 | — | — | — |
| STOK | Stoke Therapeutics, Inc. | F- | $1.8B | $27.72 | — | $28.2M | -862.1% |
| SRPT | SAREPTA THERAPEUTICS, INC. | C | $1.8B | $16.68 | — | $2B | -5.9% |
| NRIX | NURIX THERAPEUTICS, INC. | A+ | $1.8B | $16.33 | 7.10 | $701.9M | 42.0% |
| MESO | MESOBLAST LIMITED | C- | $1.8B | $13.66 | — | $65.4M | -144.3% |
| GENB | Generate Biomedicines, Inc. | not rated | $1.7B | $13.49 | — | — | — |
| ABSI | ABSCI CORP | F- | $1.7B | $10.08 | — | $1.6M | -8,050.7% |
| QURE | uniQure N.V. | F- | $1.7B | $24.61 | — | $20.2M | -1,154.8% |
| SLS | SELLAS Life Sciences Group, Inc. | not rated | $1.7B | $8.43 | — | — | — |
| RARE | ULTRAGENYX PHARMACEUTICAL INC. | C | $1.7B | $16.70 | — | $730M | -71.8% |
| PGEN | PRECIGEN, INC. | C | $1.7B | $4.71 | 47.10 | $156.9M | 15.6% |
| NVAX | NOVAVAX, INC. | F | $1.6B | $9.97 | — | $411.6M | -18.6% |
| IMCR | Immunocore Holdings plc | F- | $1.6B | $31.64 | — | $429.3M | -7.5% |
| NTLA | INTELLIA THERAPEUTICS, INC. | D- | $1.6B | $11.41 | — | $52.9M | -805.7% |
| RAPP | Rapport Therapeutics, Inc. | not rated | $1.6B | $27.00 | — | — | — |
| NBTX | Nanobiotix S.A. | C- | $1.6B | $33.00 | — | $36.4M | -73.5% |
| NUVB | Nuvation Bio Inc. | C- | $1.5B | $4.28 | — | $201.7M | -67.4% |
| OCUL | OCULAR THERAPEUTIX, INC | F- | $1.5B | $6.64 | — | $50.4M | -648.6% |
| ANAB | ANAPTYSBIO, INC. | C+ | $1.5B | $48.73 | 8.49 | $237.6M | 77.6% |
| TYRA | TYRA BIOSCIENCES, INC. | not rated | $1.4B | $20.93 | — | — | — |
| LBRX | LB Pharmaceuticals Inc | not rated | $1.4B | $44.65 | — | — | — |
| DMRA | DAMORA THERAPEUTICS, INC. | not rated | $1.4B | $23.24 | — | — | — |
| MLYS | MINERALYS THERAPEUTICS, INC. | not rated | $1.4B | $16.18 | — | — | — |
| AAPG | ASCENTAGE PHARMA GROUP INTERNATIONAL | D- | $1.4B | $15.19 | — | $96.6M | -193.4% |
| AVLN | Avalyn Pharma Inc. | not rated | $1.4B | $31.57 | — | — | — |
| TSHA | Taysha Gene Therapies, Inc. | F- | $1.4B | $4.27 | — | $5.5M | -2,844.6% |
| MNKD | MannKind Corporation | D | $1.3B | $4.18 | — | $413.4M | -18.1% |
| INVA | INNOVIVA, INC. | C+ | $1.3B | $18.86 | 9.43 | $438.3M | 44.1% |
| INBX | INHIBRX BIOSCIENCES, INC. | F- | $1.3B | $90.63 | — | $1.3M | -10,629.3% |
| OMER | OMEROS CORP | not rated | $1.3B | $18.14 | 10.55 | — | — |
| NKTR | Nektar Therapeutics | F- | $1.3B | $38.43 | — | $52.2M | -339.7% |
| URGN | UroGen Pharma Ltd. | C | $1.3B | $26.07 | — | $250.3M | -26.3% |
| ANRO | Alto Neuroscience, Inc. | not rated | $1.2B | $31.15 | — | — | — |
| DRTS | Alpha Tau Medical Ltd. | not rated | $1.2B | $14.05 | — | — | — |
| VOR | Vor Biopharma Inc. | not rated | $1.2B | $20.10 | 0.07 | — | — |
| GHRS | GH Research PLC | not rated | $1.2B | $19.22 | — | — | — |
| SGP | SpyGlass Pharma, Inc. | not rated | $1.2B | $34.90 | — | — | — |
| MLTX | MOONLAKE IMMUNOTHERAPEUTICS | not rated | $1.1B | $13.50 | — | — | — |
| VSTM | Verastem, Inc. | F- | $1.1B | $9.09 | — | $100.3M | -178.4% |
| SPTX | Seaport Therapeutics, Inc. | not rated | $1.1B | $21.26 | — | — | — |
| SVRA | Savara Inc. | not rated | $1.1B | $4.99 | — | — | — |
| JBIO | Jade Biosciences, Inc. | not rated | $1.1B | $16.56 | — | — | — |
| ODTX | Odyssey Therapeutics, Inc. | not rated | $1B | $20.94 | — | — | — |
| CRVS | Corvus Pharmaceuticals, Inc. | not rated | $968.8M | $11.49 | — | — | — |
| AKTS | Aktis Oncology, Inc. | not rated | $950.8M | $17.04 | — | — | — |
| FDMT | 4D Molecular Therapeutics, Inc. | C- | $936.9M | $12.98 | — | $92M | -217.8% |
| SLN | Silence Therapeutics plc | D- | $934.1M | $19.77 | — | $615K | -8,361.1% |
| ORIC | ORIC PHARMACEUTICALS, INC. | not rated | $930.8M | $8.98 | — | — | — |
| MGTX | MeiraGTx Holdings plc | A | $930.7M | $9.69 | 13.65 | $397.5M | 19.9% |
| PHAR | Pharming Group N.V. | A | $929.4M | $13.25 | 331.13 | $376.1M | 0.8% |
| IMTX | Immatics N.V. | not rated | $898.3M | $6.70 | — | — | — |
| LTGO | Latigo Biotherapeutics, Inc. | not rated | $897.7M | $13.54 | — | — | — |
| GLUE | Monte Rosa Therapeutics, Inc. | F- | $880.1M | $10.30 | — | $70.3M | -186.2% |
| ANNX | ANNEXON, INC. | not rated | $861.1M | $4.19 | — | — | — |
| SNDX | Syndax Pharmaceuticals, Inc. | D- | $856.4M | $9.59 | — | $289.7M | -72.3% |
| ALMS | Alumis Inc. | F- | $856.2M | $6.62 | — | $7.2M | -5,844.5% |
| SLDB | Solid Biosciences Inc. | not rated | $849.4M | $7.61 | — | — | — |
| RIGL | RIGEL PHARMACEUTICALS INC | B+ | $837.7M | $44.49 | 2.77 | $288.2M | 106.6% |
| LXRX | Lexicon Pharmaceuticals, Inc. | D- | $828.1M | $1.86 | — | $38.5M | -161.8% |
| SGMT | Sagimet Biosciences Inc. | not rated | $814.3M | $11.41 | — | — | — |
| AURA | AURA BIOSCIENCES, INC. | not rated | $792M | $7.61 | — | — | — |
| ARDX | ARDELYX, INC. | C- | $785.5M | $3.13 | — | $468.2M | -11.8% |
| PRME | Prime Medicine, Inc. | D- | $779M | $4.30 | — | $4.6M | -4,056.4% |
| IVA | Inventiva S.A. | F | $776.8M | $4.02 | — | $5M | -7,899.6% |
| ATTO | Attovia Therapeutics, Inc. | not rated | $766.8M | $16.78 | — | — | — |
| JANX | Janux Therapeutics, Inc. | C- | $755.6M | $12.35 | — | $23.3M | -428.7% |
| ACHV | Achieve Life Sciences, Inc. | not rated | $747.1M | $6.79 | — | — | — |
| OABI | OMNIAB, INC. | B | $743.9M | $5.10 | — | $40.2M | -108.1% |
| CGEM | CULLINAN THERAPEUTICS, INC. | not rated | $735.6M | $11.33 | — | — | — |
| NVCT | NUVECTIS PHARMA, INC. | not rated | $721.5M | $20.98 | — | — | — |
| CLYM | Climb Bio, Inc. | not rated | $719.5M | $12.25 | — | — | — |
| KURA | Kura Oncology, Inc. | C- | $710.2M | $7.73 | — | $79.3M | -369.3% |
| CADL | CANDEL THERAPEUTICS, INC. | not rated | $705.1M | $9.22 | — | — | — |
| ZVRA | Zevra Therapeutics, Inc. | B+ | $704.8M | $11.85 | 9.95 | $147.8M | 52.8% |
| OLMA | OLEMA PHARMACEUTICALS, INC. | not rated | $703.5M | $8.03 | — | — | — |
| AVBP | ARRIVENT BIOPHARMA, INC. | not rated | $699.3M | $13.52 | — | — | — |
| APMD | Apnimed, Inc. | not rated | $698.6M | $16.78 | — | — | — |
| BCAX | BICARA THERAPEUTICS INC. | not rated | $698.4M | $10.52 | — | — | — |
| ACRS | Aclaris Therapeutics, Inc. | F- | $689.2M | $4.35 | — | $6.4M | -1,244.1% |
| SANA | Sana Biotechnology, Inc. | not rated | $689.2M | $2.30 | — | — | — |
| DSGN | Design Therapeutics, Inc. | F | $689M | $10.76 | — | $0.00 | — |
| WVE | WAVE LIFE SCIENCES, INC. | F- | $672.6M | $3.41 | — | $70.9M | -296.9% |
| DNA | GINKGO BIOWORKS HOLDINGS, INC. | F- | $664.8M | $10.26 | — | $130.8M | -192.0% |
| CAPR | CAPRICOR THERAPEUTICS, INC. | F- | $651.8M | $11.21 | — | $0.00 | — |
| GERN | GERON CORP | not rated | $644.2M | $1.00 | — | — | — |
| IMMX | IMMIX BIOPHARMA, INC. | not rated | $619.2M | $8.66 | — | — | — |
| ABUS | ARBUTUS BIOPHARMA CORP | D+ | $595.5M | $3.89 | 3.44 | $181.5M | 121.2% |
| CBIO | Crescent Biopharma, Inc. | D- | $573.9M | $14.76 | — | $15M | -727.6% |
| RGNX | REGENXBIO Inc. | F- | $560.1M | $8.47 | — | $153.9M | -113.9% |
| ENTX | ENTERA BIO LTD. | F | $559.9M | $3.22 | — | $0.00 | — |
| DMAC | DIAMEDICA THERAPEUTICS INC. | not rated | $521.2M | $9.66 | — | — | — |
| NGNE | Neurogene Inc. | F | $518.8M | $25.06 | — | $0.00 | — |
| STTK | Shattuck Labs, Inc. | F | $512.3M | $5.03 | — | $0.00 | — |
| VALN | Valneva SE | F- | $511.9M | $5.90 | — | $174.7M | -73.7% |
| PHAT | PHATHOM PHARMACEUTICALS, INC. | B | $510.5M | $6.28 | — | $274.9M | -30.2% |
| AVTX | AVALO THERAPEUTICS, INC. | F- | $492.1M | $8.51 | — | $59K | -150,259.3% |
| GYRE | Gyre Therapeutics, Inc. | F- | $491.8M | $4.27 | — | $108.1M | -33.9% |
| JSPR | Jasper Therapeutics, Inc. | not rated | $491M | $14.76 | — | — | — |
| MDXG | MIMEDX GROUP, INC. | F | $483M | $3.31 | — | $303.7M | -6.3% |
| MNPR | Monopar Therapeutics Inc. | F | $482.3M | $71.86 | — | $0.00 | — |
| OBIO | Orchestra BioMed Holdings, Inc. | F- | $474.6M | $6.03 | — | $31.2M | -182.5% |
| RLMD | RELMADA THERAPEUTICS, INC. | not rated | $473.1M | $4.44 | — | — | — |
| CTMX | CytomX Therapeutics, Inc. | F- | $465.4M | $2.14 | — | $14M | -609.0% |
| ASMB | Assembly Biosciences, Inc. | B- | $454.9M | $22.34 | — | $72.3M | -15.4% |
| ARVN | ARVINAS, INC. | C- | $452.5M | $6.91 | — | $275.3M | -3.5% |
| PRTA | PROTHENA CORPORATION PUBLIC LIMITED COMPANY | D- | $448.8M | $8.74 | — | $52.7M | -45.4% |
| YDES | YD Bio Limited | D | $440.3M | $6.22 | — | $596.8K | -1,392.6% |
| TECX | TECTONIC THERAPEUTIC, INC. | not rated | $438.9M | $22.00 | — | — | — |
| KRSA | Korsana Biosciences, Inc. | F | $427.5M | $31.61 | — | $1.9M | -3,098.7% |
| INDP | Indaptus Therapeutics, Inc. | not rated | $426.4M | $3.20 | — | — | — |
| CNTN | CANTON STRATEGIC HOLDINGS, INC. | not rated | $422.9M | $1.95 | — | — | — |
| PBYI | PUMA BIOTECHNOLOGY, INC. | B+ | $418.2M | $8.09 | 17.59 | $231.8M | 10.3% |
| IRD | Opus Genetics, Inc. | F- | $415.6M | $4.30 | — | $7.9M | -1,726.7% |
| LYEL | Lyell Immunopharma, Inc. | F- | $414.5M | $16.86 | — | $15K | -1,701,066.7% |
| CRMD | CORMEDIX INC. | B+ | $413.9M | $5.31 | 2.59 | $462.2M | 13.8% |
| OCS | Oculis Holding AG | not rated | $397.6M | $7.61 | — | — | — |
| SPRY | ARS Pharmaceuticals, Inc. | F- | $397.1M | $3.95 | — | $122.1M | -163.6% |
| KARD | Kardigan, Inc. | not rated | $396.1M | $15.72 | — | — | — |
| RZLT | Rezolute, Inc. | not rated | $395.6M | $4.09 | — | — | — |
| ALEC | Alector, Inc. | B+ | $388.6M | $2.61 | 7.46 | $173.5M | 23.9% |
| CCCC | C4 Therapeutics, Inc. | D- | $378.2M | $2.88 | — | $32.3M | -282.2% |
| ALT | ALTIMMUNE, INC. | D- | $375.4M | $1.93 | — | $41K | -254,522.0% |
| FENC | FENNEC PHARMACEUTICALS INC. | C- | $373.5M | $10.65 | — | $59.2M | -5.5% |
| EDIT | EDITAS MEDICINE, INC. | B- | $367.3M | $2.38 | — | $49.8M | -145.0% |
| PEPG | PEPGEN INC. | not rated | $365M | $5.27 | — | — | — |
| EIKN | EIKON THERAPEUTICS, INC. | not rated | $360.2M | $6.65 | — | — | — |
| ANL | Adlai Nortye Ltd. | C | $347.1M | $10.86 | — | $5M | -710.6% |
| IMUX | Immunic, Inc. | not rated | $346.9M | $8.16 | — | — | — |
| FTH | Faeth Therapeutics, Inc. | not rated | $345M | $13.35 | — | — | — |
| PROK | ProKidney Corp. | F- | $340.2M | $1.13 | — | $775K | -13,326.7% |
| AVIR | Atea Pharmaceuticals, Inc. | not rated | $338.1M | $4.21 | — | — | — |
| ENTA | ENANTA PHARMACEUTICALS, INC | F- | $337.7M | $11.60 | — | $65.3M | -96.9% |
| GALT | GALECTIN THERAPEUTICS INC. | not rated | $332.3M | $3.30 | — | — | — |
| BNTC | BENITEC BIOPHARMA INC. | D | $329.6M | $9.45 | — | $0.00 | — |
| XFOR | X4 PHARMACEUTICALS, INC | D- | $328.8M | $3.22 | — | $17M | -474.7% |
| AUTL | AUTOLUS THERAPEUTICS PLC | C- | $327.6M | $1.23 | — | $137.4M | -186.4% |
| AGEN | AGENUS INC | D | $327.1M | $7.23 | 10.95 | $133.9M | 23.0% |
| OCGN | OCUGEN, INC. | F | $325.1M | $0.96 | — | $4.8M | -1,367.6% |
| TTRX | Turn Therapeutics Inc. | not rated | $324.7M | $10.62 | — | — | — |
| KYTX | Kyverna Therapeutics, Inc. | not rated | $323.1M | $5.11 | — | — | — |
| EPRX | EUPRAXIA PHARMACEUTICALS INC. | F | $321.2M | $8.04 | — | $0.00 | — |
| SCTX | SCRIBE THERAPEUTICS INC. | not rated | $319.3M | $16.86 | — | — | — |
| IPSC | Century Therapeutics, Inc. | C- | $317.8M | $1.75 | — | $109.2M | -90.5% |
| MPLT | MapLight Therapeutics, Inc. | not rated | $317M | $7.47 | — | — | — |
| CABA | CABALETTA BIO, INC. | not rated | $315M | $1.46 | — | — | — |
| EVMN | Evommune, Inc. | D- | $313.9M | $8.65 | — | $10M | -1,130.7% |
| ALLO | Allogene Therapeutics, Inc. | C- | $313.1M | $0.90 | — | $6.9M | -2,513.9% |
| VERU | VERU INC. | not rated | $308.9M | $2.11 | — | — | — |
| VOGX | Vogenx, Inc. | not rated | $308.5M | $20.77 | — | — | — |
| NAUT | NAUTILUS BIOTECHNOLOGY, INC. | not rated | $306.3M | $2.41 | — | — | — |
| PRLD | PRELUDE THERAPEUTICS INC | B- | $302.5M | $3.79 | — | $22.4M | -269.7% |
| FULC | FULCRUM THERAPEUTICS, INC. | F- | $286.1M | $3.75 | — | $0.00 | — |
| LRMR | LARIMAR THERAPEUTICS, INC. | not rated | $284.6M | $2.74 | — | — | — |
| LCTX | Lineage Cell Therapeutics, Inc. | F | $284.5M | $1.13 | — | $10.8M | 16.2% |
| OBX | OBSIDIAN THERAPEUTICS, INC. | F | $280.7M | $12.87 | — | $0.00 | — |
| SABS | SAB BIOTHERAPEUTICS, INC. | F- | $279.3M | $3.10 | — | $0.00 | — |
| INO | INOVIO PHARMACEUTICALS, INC. | C- | $277.2M | $1.48 | — | $298.9K | -23,798.9% |
| QTTB | Q32 Bio Inc. | B | $275.3M | $9.20 | 2.65 | $53.7M | 60.0% |
| RCKT | Rocket Pharmaceuticals, Inc. | D | $271.1M | $2.47 | — | $0.00 | — |
| ARCT | ARCTURUS THERAPEUTICS HOLDINGS INC. | F- | $268.3M | $9.31 | — | $30.5M | -285.9% |
| PLX | PROTALIX BIOTHERAPEUTICS, INC. | A+ | $264.3M | $3.14 | 12.54 | $84.7M | 24.3% |
| CAMP | CAMP4 Therapeutics Corporation | B- | $261.7M | $4.17 | — | $5.3M | -2,276.3% |
| BCYC | Bicycle Therapeutics plc | C- | $258.2M | $3.69 | — | $83.5M | -169.8% |
| CUVL | CLINUVEL PHARMACEUTICALS LIMITED | C+ | $256.7M | $5.09 | 11.07 | $64.3M | 36.0% |
| DTIL | PRECISION BIOSCIENCES INC | D- | $255.3M | $9.14 | — | $45M | -85.6% |
| LXEO | Lexeo Therapeutics, Inc. | not rated | $252.3M | $3.08 | — | — | — |
| VNDA | VANDA PHARMACEUTICALS INC. | F- | $250.9M | $4.15 | — | $229.3M | -119.9% |
| CTNM | Contineum Therapeutics, Inc. | not rated | $249M | $10.78 | — | — | — |
| IMRX | Immuneering Corporation | not rated | $245.3M | $3.79 | — | — | — |
| IRLA | Quince Therapeutics, Inc. | not rated | $242.4M | $39.53 | — | — | — |
| GLSI | GREENWICH LIFESCIENCES, INC. | not rated | $237.3M | $16.17 | — | — | — |
| ACIU | AC IMMUNE SA | D- | $229.9M | $2.26 | — | $4.5M | -1,903.0% |
| IKT | INHIBIKASE THERAPEUTICS, INC. | F | $227.9M | $1.63 | — | $0.00 | — |
| ELDN | Eledon Pharmaceuticals, Inc. | not rated | $217M | $2.67 | — | — | — |
| TRDA | ENTRADA THERAPEUTICS, INC. | F- | $213.8M | $5.46 | — | $4M | -4,058.0% |
| PALI | PALISADE BIO, INC. | F- | $209.8M | $1.17 | — | $500K | -8,739.2% |
| RNAC | Cartesian Therapeutics, Inc. | F | $208M | $6.82 | — | $1M | -12,435.2% |
| BBOT | BRIDGEBIO ONCOLOGY THERAPEUTICS, INC. | not rated | $205.8M | $2.57 | — | — | — |
| HELP | CYBIN INC. | not rated | $202.8M | $9.39 | — | — | — |
| ARTV | Artiva Biotherapeutics, Inc. | F- | $201.2M | $4.07 | — | $0.00 | — |
| ALPS | ALPS GROUP INC | not rated | $199.7M | $1.20 | — | — | — |
| OVID | Ovid Therapeutics Inc. | D- | $197.7M | $2.79 | — | $1.5M | -2,971.3% |
| KRRO | Korro Bio, Inc. | D- | $197.6M | $14.40 | — | $1.3M | -8,214.5% |
| CGEN | COMPUGEN LTD | B+ | $196.7M | $2.08 | 5.47 | $75.9M | 47.9% |
| LIMN | LIMINATUS PHARMA, INC. | not rated | $195.8M | $2.92 | — | — | — |
| PYXS | Pyxis Oncology, Inc. | D- | $195M | $1.63 | — | $13.9M | -625.7% |
| FATE | FATE THERAPEUTICS INC | F- | $194.5M | $1.60 | — | $4.8M | -2,619.6% |
| WHWK | WHITEHAWK THERAPEUTICS, INC. | F | $191.2M | $3.24 | — | $0.00 | — |
| ACOG | Alpha Cognition Inc. | D- | $189.8M | $8.72 | — | $15.3M | -153.6% |
| KROS | KEROS THERAPEUTICS, INC. | F- | $187M | $9.53 | — | $40.8M | -151.4% |
| ZNTL | Zentalis Pharmaceuticals, Inc. | F | $185.7M | $1.89 | — | $0.00 | — |
| MDWD | MEDIWOUND LTD. | F- | $177.5M | $13.83 | — | $11.9M | -170.1% |
| GTBP | GT Biopharma, Inc. | not rated | $176.8M | $3.92 | 10.59 | — | — |
| IVVD | INVIVYD, INC. | D- | $176.2M | $0.60 | — | $58.4M | -183.9% |
| SLGL | Sol-Gel Technologies Ltd. | D | $176.1M | $63.20 | — | $1.8M | -341.3% |
| CURX | Curanex Pharmaceuticals Inc | not rated | $175.6M | $5.60 | — | — | — |
| UPB | UPSTREAM BIO, INC. | F- | $174.8M | $3.19 | — | $2.9M | -5,712.3% |
| RNA | Atrium Therapeutics, Inc. | not rated | $171.7M | $7.96 | — | — | — |
| ORMP | ORAMED PHARMACEUTICALS INC. | C | $171.6M | $4.13 | — | $2M | 8,743.5% |
| STRO | SUTRO BIOPHARMA, INC. | D | $169.9M | $10.25 | — | $45.1M | -344.2% |
| ANTX | AN2 Therapeutics, Inc. | not rated | $169M | $4.46 | — | — | — |
| SION | SIONNA THERAPEUTICS, INC. | not rated | $167.1M | $3.70 | — | — | — |
| HUMA | Humacyte, Inc. | C- | $165M | $0.59 | — | $2.4M | -3,955.1% |
| TARA | Protara Therapeutics, Inc. | not rated | $161.3M | $2.62 | — | — | — |
| DRUG | BRIGHT MINDS BIOSCIENCES INC. | not rated | $160.6M | $23.35 | — | — | — |
| MBRX | Moleculin Biotech, Inc. | D | $160.1M | $8.22 | — | $0.00 | — |
| ALXO | ALX ONCOLOGY HOLDINGS INC | not rated | $154.2M | $1.12 | — | — | — |
| CMPX | COMPASS THERAPEUTICS, INC. | F | $149.5M | $0.83 | — | $0.00 | — |
| IPHA | Innate Pharma SA | F- | $149M | $1.59 | — | $10.1M | -546.1% |
| MGNX | MACROGENICS, INC. | D- | $148.6M | $2.33 | — | $154.9M | -33.2% |
| ARMP | ARMATA PHARMACEUTICALS, INC. | not rated | $141.7M | $3.81 | — | — | — |
| ZURA | Zura Bio Limited | not rated | $137.7M | $1.43 | — | — | — |
| CUE | Cue Biopharma, Inc. | D- | $137.4M | $18.92 | — | $37.7M | -435.8% |
| OKUR | ONKURE THERAPEUTICS, INC. | not rated | $135.5M | $3.35 | — | — | — |
| CLLS | Cellectis S.A. | F- | $135.4M | $1.35 | — | $56.6M | -115.4% |
| SPRB | Spruce Biosciences, Inc. | F | $133.8M | $46.54 | — | $0.00 | — |
| PRQR | ProQR Therapeutics N.V. | C- | $132.8M | $1.26 | — | $20.5M | -229.7% |
| ABEO | ABEONA THERAPEUTICS INC. | C- | $130.9M | $2.29 | — | $39M | -160.3% |
| MENS | Jyong Biotech Ltd. | not rated | $130.8M | $1.72 | — | — | — |
| NTHI | NEONC TECHNOLOGIES HOLDINGS, INC. | D | $129.8M | $4.50 | — | $40K | -107,587.6% |
| MOLN | MOLECULAR PARTNERS AG | F | $129.8M | $3.22 | — | $0.00 | — |
| LENZ | LENZ THERAPEUTICS, INC. | F- | $128.8M | $4.10 | — | $12.4M | -1,135.0% |
| NERV | Minerva Neurosciences, Inc. | not rated | $127.1M | $2.55 | — | — | — |
| ADAG | Adagene Inc. | C- | $126.2M | $2.13 | — | $7.7M | -229.6% |
| FHTX | Foghorn Therapeutics Inc. | B | $125.3M | $2.09 | 29.86 | $112.1M | 8.4% |
| IBIO | iBio, Inc. | C- | $124.4M | $0.82 | — | $1.1M | -3,244.2% |
| ENGN | enGene Therapeutics Inc. | not rated | $121.3M | $1.81 | — | — | — |
| PYPD | PolyPid Ltd | not rated | $119.9M | $6.59 | — | — | — |
| OTLK | OUTLOOK THERAPEUTICS, INC. | F+ | $117.4M | $0.48 | — | -$1.2M | 5,253.5% |
| VYGR | Voyager Therapeutics, Inc. | F- | $109.5M | $1.76 | — | $25.1M | -416.3% |
| LEXX | LEXARIA BIOSCIENCE CORP. | D- | $108.3M | $4.37 | — | $194K | -3,985.6% |
| MSLE | Satellos Bioscience Inc. | not rated | $107.1M | $6.93 | — | — | — |
| NGEN | NERVGEN PHARMA CORP. | not rated | $106.7M | $1.34 | — | — | — |
| CDXS | Codexis, Inc. | B- | $106.7M | $0.97 | — | $88.3M | -21.8% |
| NKTX | Nkarta, Inc. | D | $105.4M | $1.47 | — | $0.00 | — |
| UNCY | UNICYCIVE THERAPEUTICS, INC. | not rated | $105M | $3.77 | — | — | — |
| VANI | Vivani Medical, Inc. | F | $100.6M | $1.12 | — | $0.00 | — |
| NBP | NovaBridge Biosciences | not rated | $99.4M | $0.86 | — | — | — |
| AVXL | ANAVEX LIFE SCIENCES CORP. | not rated | $97.3M | $1.05 | — | — | — |
| ANIX | ANIXA BIOSCIENCES, INC. | not rated | $96.6M | $2.78 | — | — | — |
| HURA | TuHURA BIOSCIENCES, INC./NV | F | $96.2M | $1.51 | — | $0.00 | — |
| PMVP | PMV PHARMACEUTICALS, INC. | not rated | $94.8M | $1.26 | — | — | — |
| PLYX | Polaryx Therapeutics, Inc. | not rated | $94.7M | $1.90 | — | — | — |
| BDTX | BLACK DIAMOND THERAPEUTICS, INC. | F | $91.9M | $1.60 | — | $0.00 | — |
| ICCC | ImmuCell Corporation | B | $91.7M | $10.10 | 144.29 | $30.7M | 2.6% |
| CHRS | Coherus Oncology, Inc. | C | $90M | $0.58 | — | $53.6M | -253.4% |
| LONA | LeonaBio, Inc. | not rated | $89.4M | $3.77 | — | — | — |
| EQ | EQUILLIUM, INC. | D- | $89.4M | $1.41 | — | $41.1M | -43.8% |
| SEER | SEER, INC. | F- | $89.3M | $1.60 | — | $14.1M | -450.9% |
| NMRA | NEUMORA THERAPEUTICS, INC. | not rated | $88.3M | $0.47 | — | — | — |
| CBUS | Cibus, Inc. | C- | $87.9M | $1.15 | — | $4.5M | -2,131.4% |
| NRXS | NEURAXIS, INC. | D- | $86.9M | $6.12 | — | $6.5M | -185.2% |
| GNLX | GENELUX CORPORATION | F- | $86.4M | $1.91 | — | $8K | -444,950.0% |
| RLYB | RALLYBIO CORPORATION | A | $85.1M | $15.81 | — | $434K | 6,177.4% |
| IFRX | InflaRx N.V. | F- | $84.9M | $1.18 | — | $32.8K | -155,582.1% |
| TNYA | TENAYA THERAPEUTICS, INC. | not rated | $84.5M | $0.37 | — | — | — |
| MIST | Milestone Pharmaceuticals Inc. | not rated | $84.4M | $0.68 | — | — | — |
| ATRA | Atara Biotherapeutics, Inc. | F | $84.2M | $8.26 | — | $4M | -368.6% |
| CRBP | Corbus Pharmaceuticals Holdings, Inc. | not rated | $82.6M | $4.01 | — | — | — |
| JAGX | Jaguar Health, Inc. | C | $82.4M | $0.48 | — | $27.8M | -132.2% |
| RANI | RANI THERAPEUTICS HOLDINGS, INC. | C- | $78.9M | $0.57 | — | $6.6M | -493.0% |
| TENX | TENAX THERAPEUTICS, INC. | F | $77.2M | $1.70 | — | $0.00 | — |
| TLSA | Tiziana Life Sciences Ltd | not rated | $76M | $0.63 | — | — | — |
| TNXP | TONIX PHARMACEUTICALS HOLDING CORP. | D- | $74.6M | $3.84 | — | $43M | -420.4% |
| COYA | Coya Therapeutics, Inc. | F- | $74.6M | $3.18 | — | $4.7M | -643.5% |
| OKYO | OKYO Pharma Limited | not rated | $73.7M | $1.41 | — | — | — |
| NTRB | NUTRIBAND INC. | F- | $72.3M | $5.95 | — | $1.6M | -430.4% |
| GOSS | GOSSAMER BIO, INC. | B | $71.4M | $11.68 | — | $78.4M | -159.5% |
| MNOV | MEDICINOVA, INC. | C- | $68.9M | $1.40 | — | $920.5K | -1,168.2% |
| HRTX | HERON THERAPEUTICS, INC. /DE/ | D- | $68M | $0.36 | — | $148.2M | -14.5% |
| CSBR | CHAMPIONS ONCOLOGY, INC. | D- | $67.9M | $4.88 | — | $60.7M | -1.8% |
| ACRV | Acrivon Therapeutics, Inc. | not rated | $67.7M | $1.58 | — | — | — |
| CING | Cingulate Inc. | not rated | $67.6M | $4.65 | — | — | — |
| CNXU | CONEXEU SCIENCES INC. | not rated | $67.4M | $2.39 | — | — | — |
| VRCA | Verrica Pharmaceuticals Inc. | D- | $66.8M | $3.89 | — | $22.9M | -189.2% |
| CGTX | Cognition Therapeutics, Inc. | not rated | $64.3M | $0.68 | — | — | — |
| MAIA | MAIA BIOTECHNOLOGY, INC. | not rated | $64.2M | $1.04 | — | — | — |
| FBIO | Fortress Biotech, Inc. | B | $63.9M | $2.01 | — | $68.5M | 163.3% |
| XLO | Xilio Therapeutics, Inc. | D- | $62.5M | $8.85 | — | $55M | -20.9% |
| CLNN | Clene Inc. | C | $60.4M | $4.20 | — | $238K | -11,271.4% |
| SPRO | Spero Therapeutics, Inc. | C | $60M | $1.03 | 7.36 | $47M | 15.7% |
| XBIT | XBiotech Inc. | not rated | $59.8M | $1.96 | — | — | — |
| CRDF | CARDIFF ONCOLOGY, INC. | F- | $59.6M | $0.77 | — | $559K | -6,735.2% |
| RNXT | RENOVORX, INC. | D- | $59.3M | $1.23 | — | $2.8M | -469.0% |
| BOLD | BOUNDLESS BIO, INC. | not rated | $57.6M | $2.44 | — | — | — |
| PDSB | PDS Biotechnology Corporation | not rated | $56.5M | $1.01 | — | — | — |
| BCAB | BIOATLA, INC. | not rated | $56.1M | $1.74 | — | — | — |
| NRSN | NeuroSense Therapeutics Ltd. | not rated | $56M | $1.72 | — | — | — |
| INKT | MiNK Therapeutics, Inc. | not rated | $55.1M | $10.79 | — | — | — |
| ELOX | ELOXX PHARMACEUTICALS, INC. | D | $53.3M | $13.20 | 1.57 | $0.00 | — |
| RNTX | Rein Therapeutics, Inc. | F | $52.8M | $0.61 | — | $0.00 | — |
| ONCY | ONCOLYTICS BIOTECH INC. | not rated | $52.6M | $0.41 | — | — | — |
| AZR | AZORA THERAPEUTICS, INC. | not rated | $52.4M | $3.67 | — | — | — |
| ATNM | Actinium Pharmaceuticals, Inc. | D+ | $50.9M | $1.62 | 4.50 | $90K | 12,564.4% |
| CLGN | CollPlant Biotechnologies Ltd | D- | $50.7M | $3.96 | — | $318K | -4,130.2% |
| MREO | MEREO BIOPHARMA GROUP PLC | C | $48.8M | $0.31 | — | $500K | -5,387.6% |
| GANX | GAIN THERAPEUTICS, INC | not rated | $48.8M | $1.10 | — | — | — |
| PLRX | PLIANT THERAPEUTICS, INC. | D | $48.3M | $0.78 | — | $0.00 | — |
| HYFT | MindWalk Holdings Corp. | C- | $47.9M | $1.03 | — | $20.1M | -43.6% |
| HOWL | WEREWOLF THERAPEUTICS, INC. | not rated | $47.9M | $0.98 | — | — | — |
| IMA | ImageneBio, Inc. | C- | $47.8M | $3.84 | — | $800K | -5,415.6% |
| DWTX | Dogwood Therapeutics, Inc. | not rated | $46.3M | $1.21 | — | — | — |
| ELTX | Elicio Therapeutics, Inc. | not rated | $45.7M | $1.62 | — | — | — |
| KLRS | KALARIS THERAPEUTICS, INC. | not rated | $45.3M | $1.91 | — | — | — |
| BMEA | Biomea Fusion, Inc. | not rated | $44.4M | $0.61 | — | — | — |
| BLSM | BlossomHill Therapeutics, Inc. | not rated | $43.7M | $16.10 | — | — | — |
| TELO | Telomir Pharmaceuticals, Inc. | not rated | $43.7M | $0.59 | — | — | — |
| CNTB | Connect Biopharma Holdings Limited | C- | $43M | $0.68 | — | $3M | -2,336.3% |
| TIL | Instil Bio, Inc. | C- | $42.9M | $6.32 | — | $9M | -337.7% |
| HYPD | HYPERION DEFI, INC. | D+ | $42.3M | $2.73 | — | $1.4M | 474.9% |
| CRBU | Caribou Biosciences, Inc. | F- | $42.1M | $0.39 | — | $9.4M | -1,085.0% |
| SER | Serina Therapeutics, Inc. | D | $40.9M | $1.54 | — | $260K | -9,421.5% |
| OSTX | OS THERAPIES INCORPORATED | not rated | $40.9M | $0.89 | — | — | — |
| BRTX | BIORESTORATIVE THERAPIES, INC. | F- | $40M | $1.57 | — | $357.9K | -3,089.6% |
| GRCE | Grace Therapeutics, Inc. | not rated | $39.5M | $1.88 | — | — | — |
| GRDX | GridAI Technologies Corp. | F- | $39.4M | $5.53 | — | $36.3K | -56,864.0% |
| ALDX | ALDEYRA THERAPEUTICS, INC. | not rated | $39.2M | $0.65 | — | — | — |
| EXOZ | EXOZYMES INC. | not rated | $38.6M | $4.16 | — | — | — |
| IBO | Impact BioMedical, INC. | A | $37.2M | $4.30 | — | $38K | 4,247.4% |
| TVGN | Tevogen Inc. | not rated | $37M | $5.68 | — | — | — |
| ANVS | Annovis Bio, Inc. | F | $36M | $0.84 | — | $0.00 | — |
| NNVC | NANOVIRICIDES, INC. | F | $35.7M | $1.40 | — | $0.00 | — |
| PTHS | Pelthos Therapeutics Inc. | C- | $35.7M | $9.33 | — | $58.4M | -133.6% |
| AARD | AARDVARK THERAPEUTICS, INC. | F | $34.8M | $1.59 | — | $0.00 | — |
| INMB | INMUNE BIO INC. | D- | $34.1M | $1.10 | — | $50K | -33,332.0% |
| ESLA | ESTRELLA IMMUNOPHARMA, INC. | not rated | $33.9M | $0.78 | — | — | — |
| PMN | PROMIS NEUROSCIENCES INC. | not rated | $33.9M | $3.78 | — | — | — |
| EYPT | EyePoint, Inc. | F- | $31.5M | $0.37 | — | $2.6M | -13,281.2% |
| BCTX | BRIACELL THERAPEUTICS CORP. | not rated | $31.1M | $3.57 | — | — | — |
| SKYE | Skye Bioscience, Inc. | not rated | $30.3M | $0.86 | — | — | — |
| LITS | Lite Strategy, Inc. | D | $29.2M | $0.98 | — | $0.00 | — |
| NXTC | NextCure, Inc. | not rated | $28.8M | $6.29 | — | — | — |
| MGX | Metagenomi Therapeutics, Inc. | F- | $28.3M | $0.75 | — | $22.3M | -421.8% |
| ACET | Adicet Bio, Inc. | not rated | $27.9M | $2.98 | — | — | — |
| CNSP | CNS Pharmaceuticals, Inc. | not rated | $27.8M | $4.07 | — | — | — |
| ALGS | Aligos Therapeutics, Inc. | F- | $27.5M | $2.20 | — | $5.8M | -1,137.2% |
| ABVC | ABVC BioPharma, Inc. | D- | $26.9M | $1.00 | — | $296K | -1,322.6% |
| CRVO | CervoMed Inc. | F- | $26.8M | $1.77 | — | $8.7K | -326,822.5% |
| BYSI | BeyondSpring Inc. | D | $26.4M | $0.64 | — | $0.00 | — |
| IMMP | Immutep Limited | D- | $26.4M | $3.58 | — | $7.3M | -594.6% |
| BSEM | BioStem Technologies, Inc. | F- | $26.2M | $1.47 | — | $34.6M | -81.8% |
| ATHE | ALTERITY THERAPEUTICS LTD | not rated | $24.6M | $2.31 | — | — | — |
| ENLV | Enlivex Ltd. | not rated | $24.4M | $1.26 | 0.01 | — | — |
| FLNA | Filana Therapeutics, Inc. | not rated | $24.2M | $0.48 | — | — | — |
| EVAX | Evaxion A/S | B- | $24.2M | $2.90 | — | $7.5M | -102.4% |
| CELU | Celularity Inc. | D | $24.1M | $0.74 | — | $18.7M | -245.7% |
| APRE | Aprea Therapeutics, Inc. | not rated | $23.9M | $0.44 | — | — | — |
| CVM | CEL-SCI CORPORATION | not rated | $23.1M | $1.32 | — | — | — |
| IGC | IGC PHARMA, INC. | C- | $22.8M | $0.20 | — | $1.3M | -560.3% |
| EDSA | EDESA BIOTECH, INC. | not rated | $22.1M | $2.29 | — | — | — |
| NRXP | NRX Pharmaceuticals, Inc. | B | $21.5M | $2.43 | — | $3.4M | -691.8% |
| ICU | SeaStar Medical Holding Corporation | D- | $21.4M | $1.89 | — | $2.2M | -678.2% |
| ATOS | ATOSSA THERAPEUTICS, INC. | not rated | $20.3M | $2.03 | — | — | — |
| APLM | Apollomics Inc. | B | $20.1M | $18.25 | — | $8.5M | -128.7% |
| COCP | COCRYSTAL PHARMA, INC. | not rated | $19.9M | $1.04 | — | — | — |
| CNTX | CONTEXT THERAPEUTICS INC. | not rated | $19.6M | $0.21 | — | — | — |
| KTTA | PASITHEA THERAPEUTICS CORP. | not rated | $18.4M | $0.55 | — | — | — |
| LPCN | LIPOCINE INC. | D- | $17.7M | $1.60 | — | $3.7M | -249.2% |
| TVRD | TVARDI THERAPEUTICS, INC. | C- | $17.5M | $1.31 | — | $7.6M | -344.2% |
| ATYR | ATYR PHARMA, INC. | F- | $17.4M | $6.81 | — | $190K | -28,065.3% |
| ABOS | Acumen Pharmaceuticals, Inc. | not rated | $16.9M | $0.23 | — | — | — |
| GOVX | GEOVAX LABS, INC. | F | $15.9M | $2.16 | — | $0.00 | — |
| MRKR | MARKER THERAPEUTICS, INC. | D- | $15.8M | $0.95 | — | $3.9M | -220.5% |
| YARW | YARROW BIOSCIENCE, INC. | D- | $15.5M | $18.10 | — | $482K | -3,881.5% |
| MCRB | Seres Therapeutics, Inc. | D- | $15.4M | $1.51 | — | $2.1M | -2,209.6% |
| ALLR | Allarity Therapeutics, Inc. | B- | $15.2M | $0.95 | — | $345K | -3,575.1% |
| KYNB | KYNTRA BIO, INC. | F | $15.1M | $3.74 | — | $4.6M | 3,967.8% |
| ONCO | Onconetix, Inc. | F- | $14.8M | $3.76 | — | $645.8K | -1,578.8% |
| PLUR | Pluri Inc. | F | $14.8M | $1.20 | — | $1M | -2,344.6% |
| BCDA | BioCardia, Inc. | F | $13.9M | $0.92 | — | $0.00 | — |
| DYAI | DYADIC INTERNATIONAL INC | F- | $13.8M | $0.38 | — | $3.8M | -200.5% |
| BIVI | BIOVIE INC. | not rated | $13.5M | $1.26 | — | — | — |
| CTXR | Citius Pharmaceuticals, Inc. | not rated | $13.2M | $0.48 | — | — | — |
| NCEL | NewcelX Ltd. | not rated | $13.1M | $2.74 | — | — | — |
| TCRX | TSCAN THERAPEUTICS, INC. | F- | $12.6M | $0.19 | — | $7.1M | -1,618.4% |
| ELAB | PMGC HOLDINGS INC. | D- | $12.5M | $1.54 | — | $2.6M | -523.0% |
| PTN | PALATIN TECHNOLOGIES, INC. | B- | $12.3M | $6.90 | — | $13.2M | -63.6% |
| NIKI | Niki BioSolutions, Inc. | not rated | $12.3M | $1.67 | — | — | — |
| PASG | Passage BIO, Inc. | not rated | $12.2M | $3.81 | — | — | — |
| KAPA | KAIROS PHARMA, LTD. | not rated | $12.1M | $0.51 | — | — | — |
| KZIA | Kazia Therapeutics Limited. | F | $12.1M | $7.46 | 6.57 | $29.5K | -54,287.3% |
| BOLT | Bolt Biotherapeutics, Inc. | F- | $12M | $6.25 | — | $4.7M | -553.6% |
| CLRB | Cellectar Biosciences, Inc. | not rated | $11.8M | $1.18 | — | — | — |
| AZTR | Azitra, Inc. | F- | $11.7M | $0.61 | — | $0.00 | — |
| GUTS | Fractyl Health, Inc. | F- | $11.6M | $0.87 | — | $0.00 | — |
| INTS | INTENSITY THERAPEUTICS, INC. | not rated | $11.2M | $3.38 | — | — | — |
| HIND | VYOME HOLDINGS, INC. | F- | $10.8M | $1.54 | — | $129.7K | -8,716.8% |
| LSTA | Lisata Therapeutics, Inc. | D- | $10.7M | $1.19 | — | $100K | -14,621.0% |
| DARE | Dare Bioscience, Inc. | C- | $10.7M | $0.70 | — | $1.4M | -804.4% |
| ARTL | ARTELO BIOSCIENCES, INC. | not rated | $10M | $2.18 | — | — | — |
| GDTC | CytoMed Therapeutics Limited | D- | $10M | $0.85 | — | $253.7K | -1,227.1% |
| CMMB | SNOWDRIFT PARENT CORPORATION | not rated | $9.9M | $1.38 | — | — | — |
| INAB | IN8BIO, INC. | not rated | $9.8M | $0.91 | — | — | — |
| RADX | Radiopharm Theranostics Limited | F- | $9.7M | $0.82 | — | $3.6M | -1,055.3% |
| MTVA | METAVIA INC. | not rated | $9.5M | $1.44 | — | — | — |
| CALC | CalciMedica, Inc. | not rated | $8.8M | $1.27 | — | — | — |
| AEON | AEON Biopharma, Inc. | not rated | $8.6M | $0.17 | — | — | — |
| VTGN | VISTAGEN THERAPEUTICS, INC. | F- | $8.3M | $0.19 | — | $2.5M | -2,702.6% |
| SNGX | SOLIGENIX, INC. | not rated | $7.5M | $0.32 | — | — | — |
| TOVX | Theriva Biologics, Inc. | not rated | $7.4M | $0.16 | — | — | — |
| ACTU | ACTUATE THERAPEUTICS, INC. | not rated | $7.3M | $0.31 | — | — | — |
| IMRN | IMMURON LIMITED | D- | $7.2M | $0.89 | — | $5.1M | -71.6% |
| ENVB | ENVERIC BIOSCIENCES, INC. | not rated | $6.8M | $1.52 | — | — | — |
| ENSC | Ensysce Biosciences, Inc. | D- | $6.8M | $0.35 | — | $4.5M | -280.5% |
| XCUR | EXICURE, INC. | F | $6.8M | $1.04 | — | $0.00 | — |
| ALZN | ALZAMEND NEURO, INC. | not rated | $6.4M | $1.34 | — | — | — |
| BLRX | BioLineRx Ltd | C- | $6.4M | $1.48 | — | $1.4M | -145.5% |
| FBLG | FibroBiologics, Inc. | not rated | $6.2M | $0.94 | — | — | — |
| LTRN | LANTERN PHARMA INC. | not rated | $6.2M | $0.49 | — | — | — |
| CNSY | CERENOME, INC. | F- | $6.1M | $0.80 | — | $4.2M | -620.7% |
| KPRX | KIORA PHARMACEUTICALS, INC. | D | $5.9M | $1.33 | — | $0.00 | — |
| CDIO | Cardio Diagnostics Holdings, Inc. | B- | $5.8M | $1.96 | — | $15.2K | -42,721.9% |
| TPST | Tempest Therapeutics, Inc. | not rated | $5.8M | $0.39 | — | — | — |
| CMND | Clearmind Medicine Inc. | not rated | $5.8M | $4.95 | — | — | — |
| MTNB | MATINAS BIOPHARMA HOLDINGS, INC. | not rated | $5.6M | $0.88 | — | — | — |
| ACXP | Acurx Pharmaceuticals, Inc. | not rated | $5.5M | $1.04 | — | — | — |
| PCSA | Processa Pharmaceuticals, Inc. | not rated | $5.2M | $1.87 | — | — | — |
| PULM | Pulmatrix, Inc. | C- | $5.1M | $1.39 | — | $7.8M | -51.4% |
| CVKD | Cadrenal Therapeutics, Inc. | not rated | $4.9M | $1.37 | — | — | — |
| SNTI | Senti Biosciences Holdings, Inc. | F- | $4.9M | $0.16 | — | $55K | -90,116.4% |
| CELZ | CREATIVE MEDICAL TECHNOLOGY HOLDINGS, INC. | D- | $4.7M | $0.62 | — | $3K | -249,160.1% |
| IMNN | Imunon, Inc. | not rated | $4.7M | $0.72 | — | — | — |
| PMCB | PHARMACYTE BIOTECH, INC. | D | $4.6M | $0.43 | — | $0.00 | — |
| XTLB | XTL BIOPHARMACEUTICALS LTD. | F | $4.5M | $1.91 | — | $451K | -1,545.2% |
| AIM | AIM ImmunoTech Inc. | D | $4.5M | $0.15 | — | $95K | -15,021.1% |
| XBIO | XENETIC BIOSCIENCES, INC. | D- | $4.2M | $1.80 | — | $3.3M | -75.9% |
| OSRH | OSR HEALTH, INC. | D- | $4.1M | $0.12 | — | $1.8M | -824.4% |
| TCRT | Alaunos Therapeutics, Inc. | D- | $4.1M | $1.61 | — | $3K | -133,666.7% |
| PHIO | Phio Pharmaceuticals Corp | not rated | $4M | $0.84 | — | — | — |
| GRI | GRI BIO, INC. | not rated | $4M | $1.84 | — | — | — |
| TRAW | Traws Pharma, Inc. | D- | $3.8M | $0.24 | — | $2.8M | -773.0% |
| AGMB | AgomAb Therapeutics NV | not rated | $3.8M | $6.93 | — | — | — |
| DRMA | DERMATA THERAPEUTICS, INC. | not rated | $3.5M | $0.71 | — | — | — |
| ADXN | Addex Therapeutics Ltd | D- | $3.5M | $2.81 | — | $36.4K | -22,448.4% |
| MBIO | MUSTANG BIO, INC. | not rated | $3.4M | $0.45 | — | — | — |
| ERNA | Ernexa Therapeutics Inc. | not rated | $3.3M | $1.95 | — | — | — |
| EVGN | EVOGENE LTD. | F | $3.2M | $0.37 | — | $1.3M | -551.3% |
| SILO | SILO PHARMA, INC. | F- | $2.9M | $1.83 | — | $54.1K | -8,269.5% |
| REVB | REVELATION BIOSCIENCES, INC. | not rated | $2.9M | $4.23 | — | — | — |
| VRAX | Virax Biolabs Group Ltd | C- | $2.2M | $0.60 | — | $6.3K | -95,739.2% |
| SLXN | Silexion Therapeutics Corp | not rated | $2.2M | $3.23 | — | — | — |
| QNTM | Quantum BioPharma Ltd. | not rated | $2.2M | $1.95 | — | — | — |
| PPCB | PROPANC BIOPHARMA, INC. | not rated | $2M | $1.74 | — | — | — |
| GNPX | Genprex, Inc. | D | $1.8M | $2.25 | — | $0.00 | — |
| SXTP | 60 DEGREES PHARMACEUTICALS, INC. | D- | $1.8M | $0.52 | — | $1.1M | -729.9% |
| SCNI | SCINAI IMMUNOTHERAPEUTICS LTD. | B- | $1.8M | $0.51 | — | $3.1M | -270.9% |
| CLDI | Calidi Biotherapeutics, Inc. | not rated | $1.7M | $0.68 | — | — | — |
| JUNS | JUPITER NEUROSCIENCES, INC. | F | $1.7M | $2.21 | — | $21.8K | -42,206.9% |
| PBM | PSYENCE BIOMEDICAL LTD | not rated | $1.7M | $3.03 | — | — | — |
| HCWB | HCW Biologics Inc. | B- | $1.7M | $0.91 | — | $6.7M | -83.8% |
| OGEN | ORAGENICS, INC. | not rated | $1.6M | $0.36 | — | — | — |
| APVO | Aptevo Therapeutics Inc. | not rated | $1.4M | $0.76 | — | — | — |
| BDRX | Biodexa Pharmaceuticals PLC | not rated | $1.3M | $2.44 | — | — | — |
| RNAZ | TRANSCODE THERAPEUTICS, INC. | not rated | $1.3M | $1.38 | — | — | — |
| CANF | Can-Fite BioPharma Ltd. | F- | $1.3M | $1.57 | — | $405K | -2,426.7% |
| CRIS | CURIS, INC. | F- | $1.2M | $0.60 | — | $4.3M | -490.3% |
| BBLG | Bone Biologics Corporation | not rated | $1.2M | $0.36 | — | — | — |
| LABT | Lakewood-Amedex Biotherapeutics Inc. | not rated | $903.6K | $0.38 | — | — | — |
| VIVS | VivoSim Labs, Inc. | F | $797.4K | $0.15 | — | $112K | -11,016.1% |
| HLSQ | BiomX Inc. | not rated | $739.4K | $0.07 | — | — | — |
| DCOY | Decoy Therapeutics Inc. | not rated | $710.9K | $1.09 | — | — | — |
| QNRX | Quoin Pharmaceuticals, Ltd. | not rated | $667.8K | $3.80 | — | — | — |
| EDVA | Endovia Health Sciences, Inc. | D | $548.9K | $0.18 | — | $32.1K | -53,856.5% |
| PLRZ | Polyrizon Ltd. | not rated | $503.9K | $11.11 | 2.27 | — | — |
| LGVN | LONGEVERON INC. | F- | $449.8K | $3.25 | — | $1.2M | -1,921.7% |
| VBIO | Valion Bio, Inc. | F- | $435.4K | $0.49 | — | $482K | -3,890.0% |
| CDT | CDT EQUITY INC. | not rated | $402.1K | $0.51 | — | — | — |
| SRZN | Surrozen, Inc./DE | D | $374.6K | $31.82 | — | $10.5M | -3,706.4% |
| SPRC | SCISPARC LTD. | F- | $144.5K | $0.40 | — | $679K | -1,793.7% |
| NEUP | Neuphoria Therapeutics Inc. | F- | $81.2K | $2.70 | — | $1.2M | -1,145.7% |
| KALA | KALA BIO, INC. | F | $12.7K | $0.17 | — | $0.00 | — |
| KPTI | Karyopharm Therapeutics Inc. | C | $503.52 | $0.02 | — | $146.6M | -153.3% |
| PPBT | PURPLE BIOTECH LTD. | not rated | $331.24 | $1.38 | — | — | — |
| ADRX | ADARx Pharmaceuticals, Inc. | not rated | — | $13.25 | — | — | — |
| APGE | Apogee Therapeutics, Inc. | not rated | — | $135.07 | — | — | — |
| ATAI | AtaiBeckley Inc. | not rated | — | $7.35 | — | $4.1M | -16,142.0% |
| BRNS | BARINTHUS BIOTHERAPEUTICS PLC | D- | — | $0.74 | — | $0.00 | — |
| CRNX | Crinetics Pharmaceuticals, Inc. | D- | — | $84.95 | — | $42.2M | -1,189.9% |
| ETRA | Electra Therapeutics, Inc. | not rated | — | $9.42 | — | — | — |
| FBRX | FORTE BIOSCIENCES, INC. | not rated | — | $76.99 | — | — | — |
| LNAI | LUNAI BIOWORKS INC. | B | — | $0.16 | — | $52K | -6,852.0% |
| MLEC | MOOLEC SCIENCE SA | B | — | $0.85 | — | $333.6M | -52.9% |
| SLBT | SL Science Holding Ltd | not rated | — | $0.68 | — | — | — |
| TBPH | Theravance Biopharma, Inc. | C | — | $17.03 | — | $104.3M | 51.6% |
| VCRE | Vicore Pharma Holding AB | not rated | — | $11.03 | — | — | — |
| VRXA | Veraxa Biotech Holding AG | not rated | — | $1.28 | — | — | — |
| VTVT | vTv Therapeutics Inc. | C- | — | $21.55 | — | $36.8M | -20.8% |
Fundamentals from SEC filings, prices from the last market-data pass. Sort by any column; companies with no figure sort last either way.
Sorted by market cap, largest first; click any column to re-sort. Companies with no figure sort last either way, because a missing P/E means unprofitable rather than cheap. Nothing here is a recommendation.