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1. 1Some medicines rely on licenses or partnerships with other companies. For example, a subsidiary licenses patent families related to DARZALEX from Genmab, and IMBRUVICA is co-commercialized in the United States with Pharmacyclics, an AbbVie company.
2. 2The company depends on government approvals and ongoing oversight for its medicines and medical devices, including rules on safety, manufacturing, labeling and sales.
3. 3Sales depend partly on health insurers and government programs deciding whether to cover products and how much they will reimburse; U.S. and other governments can also change medicine-pricing rules.
4. 4The company uses third parties to make or supply some products and relies on complex international manufacturing and distribution chains.