Rankings · Quality

Highest return on capital

Graded A or B, ranked by operating profit as a share of the equity and debt the business runs on. Banks, insurers and companies with negative equity are left out, where the measure means nothing.

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Size
Any sizeOver $10B$1B to $10B
Sector
All sectorsHealthcareFinancialsTechnologyIndustrialsEnergyCommunication ServicesConsumer StaplesMaterialsConsumer DiscretionaryReal EstateUtilities

154 companies meet this test

Figures as of September 30, 2026

#CompanyGradeReturn on capitalNet marginMarket value
1MEDPMedpace Holdings, Inc.A+75.7%17.7%$17.4B
2IDXXIDEXX LABORATORIES INC /DEA+50.5%25.0%$42B
3PAHCPhibro Animal Health CorporationB32.0%6.6%$1.5B
4EXELExelixis IncA+31.2%35.3%$14.5B
5NUTXNUTEX HEALTH INC.B+29.8%21.2%$1.4B
6ADMAADMA BIOLOGICS, INC.A+28.4%33.0%$2.2B
7ALNYALNYLAM PHARMACEUTICALS, INC.A+24.0%19.7%$34B
8INCYINCYTE CORPORATIONA+23.0%26.7%$24.6B
9CHECHEMED CORPORATIONB+22.7%10.6%$6.7B
10IRMDIRADIMED CORPORATIONA+22.0%26.7%$1.1B
11RMDResMed Inc.B+20.2%26.9%$32.2B
12GSKGSK plcA+19.2%17.5%$106.5B
13CORCENCORA, INC.A19.2%0.8%$58.7B
14ILMNILLUMINA, INC.B+19.1%18.4%$41.1B
15DXCMDEXCOM, INC.A+17.6%20.1%$32.7B
16VRTXVERTEX PHARMACEUTICALS INC / MAB+17.4%35.0%$133.5B
17DOCSDoximity, Inc.A+16.9%25.5%$5.1B
18TEVATEVA PHARMACEUTICAL INDUSTRIES LIMITEDA16.5%4.1%$46.3B
19GILDGILEAD SCIENCES, INC.A16.4%-10.6%$187.6B
20UTHRUnited Therapeutics CorporationB+16.3%41.6%$20.7B
21THCTENET HEALTHCARE CORPA+16.2%14.6%$20.8B
22HALOHALOZYME THERAPEUTICS, INC.A+15.5%24.9%$12.7B
23HRMYHARMONY BIOSCIENCES HOLDINGS, INC.A+15.3%18.9%$2.3B
24PODDINSULET CORPORATIONB+15.1%12.3%$9.2B
25AZNASTRAZENECA PLCA+14.5%16.7%$256.5B

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A ranking orders companies by one stated measure. It is not a recommendation, and it says nothing about whether any share price is reasonable.